John Canty
Medicine
345 Biomedical Research Building
3435 Main Street
Buffalo, NY 14214
Phone: 829-2663
Fax: 829-2665
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OFFICE LOCATIONS
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UBMD Internal Medicine 3980 Sheridan Dr. 6th Floor Amherst, NY 14226 Phone: 716-882-6544 Fax: 716-882-6833 Hours: 8am-4:30pm View Map |
Insurance Accepted Aetna U.S. Healthcare Better Health Plan, Inc. (HMO) Community Blue (HMO) Empire Fidelis GHI Independent Health Association (HMO) United Healthcare Univera Health Care (HMO) |
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University at Buffalo Biomedical Research Bldg. Rm 345 3435 Main Street Buffalo, NY 14214 Phone: (716)829-2495 Fax: (716)829-2665 View Map |
DESCRIPTION OF INTERESTS
| As Chief of the Division of Cardiovascular Medicine, I am responsible for overseeing the clinical, teaching and research programs of the Division of Cardiology at the University at Buffalo. I see outpatients in our ambulatory cardiology practice as well as attend in the CCU at the Buffalo General Hospital and Department of Veterans Affairs Medical Center. We are currently transitioning all of the cardiovascular programs to the new Global Heart and Vascular Hospital adjacent to the Buffalo General Hospital. On top of this new facility will be the UB Clinical and Translational Research Center which will house laboratories, a clinical research center and a new translational cardiovascular imaging facility. We look forward to occupancy of this innovative, state-of-the art facility in early 2012. In terms of scientific investigation, our group has a longstanding interest in understanding the adaptive and maladaptive responses of the heart to chronic repetitive ischemia. We conduct translational research in preclinical models of ischemic heart disease and pursue parallel patient oriented investigation in humans with chronic coronary artery disease. Basic investigation involves three major areas which are all directly relevant to human cardiovascular disease and are summarized below. The first area focuses on identifying the intrinsic adaptive responses of the heart that arise from repetitive ischemia or angina and result in viable, chronically dysfunctional or “hibernating myocardium”. This is an important pathophysiological state to identify clinically since in contrast to a heart attack where the muscle is scarred, left ventricular dysfunction is at least partially reversible with revascularization. To accomplish investigation with this problem, we use high throughput proteomic approaches employing 2D-differential in gel electrophoresis and mass spectrometry as well as transcriptional profiling with gene arrays (in collaboration with colleagues at the New York State Center of Bioinformatics and Life Sciences). We have identified that myocyte cellular remodeling, rather than fibrosis, accounts for the persistent dysfunction frequently observed after coronary revascularization. With this information, we can identify new molecular targets for therapeutic intervention. The second area of investigation involves studies centered on understanding the mechanisms responsible for effecting intrinsic cardiac repair with resident adult stem cell populations residing in the bone marrow and heart. We have demonstrated that a number of diverse interventions (e.g. adenoviral overexpression of FGF-5, selected cholesterol lowering medication such as pravastatin and intracoronary mesenchymal stem cells) all improve myocardial function yet have no effect on myocardial blood flow. The functional improvement appears to arise from endogenous myocyte proliferation which, with each intervention, is accompanied by mobilization of cKit+ and CD133+ bone marrow progenitor cells to the heart. These interventions all stimulate cardiac myocytes to reenter the cell cycle and replace myocytes that were lost via apoptosis during repetitive ischemia. They afford a great potential to effect cardiac repair in pathophysiological states that are not due to irreversible fibrosis. This work is highly relevant to advancing therapeutic options available for patients with heart failure. The third area of study centers on understanding how chronic ischemia and cellular remodeling predisposes to the development of sudden cardiac arrest form ventricular fibrillation. We have demonstrated considerable spatial inhomogeneity in function, perfusion, cellular and molecular remodeling in hibernating myocardium that results in a substrate that develops spontaneous ventricular fibrillation in the absence of overt evidence of acute ischemia or infarction. We can identify this substrate in vivo by using molecular imaging of myocardial sympathetic innervation with positron emission tomography (PET) and 11C-meta-hydroxyephedrine (HED) which is severely reduced in hibernating myocardium. We are currently pursuing investigation to determine whether continuous telemetry or circulating biomarkers can also be used to predict the remodeling that leads to an increased susceptibility to sudden cardiac arrest from ventricular fibrillation. Our long-term goal is to identify whether there are substrate markers that can better predict the likelihood that spontaneous arrhythmias develop prior to cardiac arrest. This is important since approximately one in three patients present with sudden death in the absence of a heart attack as their first and only manifestation of heart disease. Finally, we are actively involved in extending our findings in the laboratory to the care of patients with heart disease. As an example, we have translated our preclinical observations to humans through an NIH sponsored clinical trial intended to determine whether imaging myocardial scar or reduced norepinephrine uptake in viable, dysfunctional myocardium with HED and PET can identify a substrate predictive of an increased risk of sudden cardiac death in patients with chronic left ventricular dysfunction. The PAREPET study (Prediction of Arrhythmic Events with Positron Emission Tomography) will determine whether PET imaging can be used to risk stratify patients for sudden death who will be the most likely to benefit from implantation of an implantable cardiac defibrillator (ICD). If successful, this approach could help identify a patient population with relatively preserved left ventricular function who would benefit from the primary prevention of sudden cardiac death by placement of an implantable cardiac defibrillator. While the rate of sudden death events is lower in this group, they account for a large number of events. Our academic environment provides a rich opportunity for training in translational cardiovascular medicine. Our long-term goal is to advance the care of patients with heart disease through clinical practice and scientific investigation. Through scientific advances, we hope to contribute to preventing the progression of heart failure and preventing the development of sudden cardiac death. |
SPECIALTIES
Cardiology
Cardiovascular Disease
EDUCATION
| 1979 | Doctor of Medicine, Medicine University of New York at Buffalo Thesis Honors |
| 1975 | Bachelor of Science, Biomedical Engineering Rensselaer Polytechnic Institute Cum Laude |
PUBLICATIONS
| Fallavollita JA, Banas MD, Suzuki G, deKemp RA, Sajjad M, Canty JM; 11C-meta-hydroxyephedrine defects persist despite functional improvement in hibernating myocardium.; J Nucl Cardiol; 2010 Jan; 17(1); 85-96 |
| Hu Q, Suzuki G, Young RF, Page BJ, Fallavollita JA, Canty JM; Reductions in mitochondrial O(2) consumption and preservation of high-energy phosphate levels after simulated ischemia in chronic hibernating myocardium.; Am J Physiol Heart Circ Physiol; 2009 Jul; 297(1); 223-232 |
| Duan X, Young R, Straubinger RM, Page B, Cao J, Wang H, Yu H, Canty JM, Qu J; A straightforward and highly efficient precipitation/on-pellet digestion procedure coupled with a long gradient nano-LC separation and Orbitrap mass spectrometry for label-free expression profiling of the swine heart mitochondrial proteome.; J Proteome Res; 2009 Jun; 8(6); 2838-2850 |
| Suzuki G, Iyer V, Cimato T, Canty JM; Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle.; Circ Res; 2009 Jan; 104(2); 255-264 |
| Baldwa S, Rana M, Canty JM, Fallavollita JA; Comparison of thallium deposition with segmental perfusion in pigs with chronic hibernating myocardium.; Am J Physiol Heart Circ Physiol; 2008 Dec; 295(6); 2522-2529 |
| Jing D, Parikh A, Canty JM, Tzanakakis ES; Stem cells for heart cell therapies.; Tissue Eng Part B Rev; 2008 Dec; 14(4); 393-406 |
| Lin H, Shabbir A, Molnar M, Yang J, Marion S, Canty JM, Lee T; Adenoviral expression of vascular endothelial growth factor splice variants differentially regulate bone marrow-derived mesenchymal stem cells.; J Cell Physiol; 2008 Aug; 216(2); 458-468 |
| Canty JM, Iyer VS; Hydrogen peroxide and metabolic coronary flow regulation.; J Am Coll Cardiol; 2007 Sep; 50(13); 1279-1281 |
| Fallavollita JA, Luisi AJ, Michalek SM, Valverde AM, deKemp RA, Haka MS, Hutson AD, Canty JM; Prediction of arrhythmic events with positron emission tomography: PAREPET study design and methods.; Contemp Clin Trials; 2006 Aug; 27(4); 374-388 |
| Banas, M.D. Young, H. Fallavollita, J.A. Canty, J.M., Jr.; Persistent reductions in flow and function after revascularization of swine with hibernating myocardium.; Journal of the American College of Cardiology; 2006; |
| Ovchinnikov V, Suzuki G, Canty JM, Fallavollita JA; Blunted functional responses to pre- and postjunctional sympathetic stimulation in hibernating myocardium.; Am J Physiol Heart Circ Physiol; 2005 Oct; 289(4); 1719-1728 |
| Iyer VS, Canty JM; Regional desensitization of beta-adrenergic receptor signaling in swine with chronic hibernating myocardium.; Circ Res; 2005 Oct; 97(8); 789-795 |
| Luisi AJ, Suzuki G, Dekemp R, Haka MS, Toorongian SA, Canty JM, Fallavollita JA; Regional 11C-hydroxyephedrine retention in hibernating myocardium: chronic inhomogeneity of sympathetic innervation in the absence of infarction.; J Nucl Med; 2005 Aug; 46(8); 1368-1374 |
| Suzuki, G. Lee, T.C. Fallavollita, J.A. Canty, J.M., Jr.; Adenoviral gene transfer of FGF-5 to hibernating myocardium improves function and stimulates myocytes to hypertrophy and reenter the cell cycle.; Circulation Research; 2005; 96; 767-775 |
| Gangasani, A. Sidhu, S. Fallavollita, J.A. Korotchkina, L. G. Suzuki, G. Patel, M.S. Canty, J.M., Jr.; Cardiac pyruvate dehydrogenase complex (PDC) deficiency in mice leads to myocardial hypertrophy and cardiomyopathy.; Circulation; 2005; 112(II); II-21-II-22 |
| Luisi AJ Fallavollita, J.A. Luisi, A.J. Valverde, A.M. Michalek, S.M. Heavey, B.M. Canty, J.M.; Electrocardiographic risk stratification of sudden cardiac death.; J Electrocardiol; 2005; 35(4S); 140-140 |
| Canty, J. M. Fallavollita, J. A.; Hibernating myocardium; J Nucl Cardiol; 2005; 12(1); 104-119 |
| Canty JM, Fallavollita JA; Hibernating myocardium.; J Nucl Cardiol; 2005 Jan; 12(1); 104-119 |
| Fallavollita, J.A. Riegel, B.J. Suzuki, G. Valeti, U. Canty, J.M., Jr.; Mechanism of sudden cardiac death in pigs with viable chronically dysfunctional myocardium and ischemic cardiomyopathy; American Journal of Physiology - Heart & Circulatory Physiology; 2005; 289; H2688-H2696 |
| Luisi AJ Canty, J.M., Jr. deKemp, R.A. Haka, M.S. Toorongian, S.A. Fallavollita, J.A.; Patients with ischemic cardiomyopathy eligible for ICD therapy demonstrate extensive sympathetic denervation out of proportion to previous infarction.; Circulation; 2005; 112; 472-472 |
| Fallavollita JA, Valeti U, Oza S, Canty JM; Spatial heterogeneity of endocardial voltage amplitude in viable, chronically dysfunctional myocardium.; Basic Res Cardiol; 2004 May; 99(3); 212-222 |
| Canty JM, Suzuki G, Banas MD, Verheyen F, Borgers M, Fallavollita JA; Hibernating myocardium: chronically adapted to ischemia but vulnerable to sudden death.; Circ Res; 2004 Apr; 94(8); 1142-1149 |
| Canty JM, Suzuki G, Banas MD, Verheyen F, Borgers M, Fallavollita JA; Hibernating Myocardium. Chronically Adapted to Ischemia but Vulnerable to Sudden Death.; Circ Res; 2004 Mar; |
| Thijssen VL, Borgers M, Lenders MH, Ramaekers FC, Suzuki G, Palka B, Fallavollita JA, Thomas SA, Canty JM Jr; Temporal and Spatial Variations in Structural Protein Expression During the Progression From Stunned to Hibernating Myocardium; Circulation; 2004; 110(21); 2213-2221 |
| Canty JM, Fallavollita JA; Sympathetic nerves and myocyte necrosis: more than meets the eye.; Circ Res; 2003 Oct; 93(9); 796-798 |
| Fallavollita JA, Malm BJ, Canty JM; Hibernating myocardium retains metabolic and contractile reserve despite regional reductions in flow, function, and oxygen consumption at rest.; Circ Res; 2003 Jan; 92(1); 48-55 |
| Iyer VS Young,R.F. Lee,T.C. Nowak,N. Canty,J.M.,Jr.; Microarray analysis of differential gene expression in hibernating myocardium is consistent with regional remodeling and local neurohumoral activation; FASEB J; 2003; 17(4); A530-A530 |
| Iyer VS Canty,J.M.,Jr.; Regional reductions in b-adrenergic receptor mediated cAMP prpoduction and reciprocal alterations in Ga protein expression in swine with hibernating myocardium; FASEB J; 2003; 17(4); A843-A843 |
| Malm BJ, Suzuki G, Canty JM, Fallavollita JA; Variability of contractile reserve in hibernating myocardium: dependence on the method of inotropic stimulation.; Cardiovasc Res; 2002 Dec; 56(3); 422-432 |
| Thomas SA, Fallavollita JA, Suzuki G, Borgers M, Canty JM; Dissociation of regional adaptations to ischemia and global myolysis in an accelerated Swine model of chronic hibernating myocardium.; Circ Res; 2002 Nov; 91(10); 970-977 |
| Luisi AJ, Fallavollita JA, Suzuki G, Canty JM; Spatial inhomogeneity of sympathetic nerve function in hibernating myocardium.; Circulation; 2002 Aug; 106(7); 779-781 |
| Fallavollita JA, Logue M, Canty JM; Coronary patency and its relation to contractile reserve in hibernating myocardium.; Cardiovasc Res; 2002 Jul; 55(1); 131-140 |
| Fallavollita JA, Canty JM; Ischemic cardiomyopathy in pigs with two-vessel occlusion and viable, chronically dysfunctional myocardium.; Am J Physiol Heart Circ Physiol; 2002 Apr; 282(4); 1370-1379 |
| Canty JM, Lee TC; Troponin I Proteolysis and Myocardial Stunning: Now You See It-Now You Don't.; J Mol Cell Cardiol; 2002 Apr; 34(4); 375-377 |
| Canty JM Jr, Suzuki G; Heterogeneity of apoptosis and myolysis in coronary microembolization: A competition between programmed cell death and programmed cell survival; European Heart Journal; 2002; 23(11); 838-840 |
| Fallavollita JA, Lim H, Canty JM; Myocyte apoptosis and reduced SR gene expression precede the transition from chronically stunned to hibernating myocardium.; J Mol Cell Cardiol; 2001 Nov; 33(11); 1937-1944 |
| Canty JM, Fallavollita JA; Lessons from experimental models of hibernating myocardium.; Coron Artery Dis; 2001 Aug; 12(5); 371-380 |
| Dube S, Canty JM; Shear stress-induced vasodilation in porcine coronary conduit arteries is independent of nitric oxide release.; Am J Physiol Heart Circ Physiol; 2001 Jun; 280(6); 2581-2590 |
| Fallavollita JA, Logue M, Canty JM; Stability of hibernating myocardium in pigs with a chronic left anterior descending coronary artery stenosis: absence of progressive fibrosis in the setting of stable reductions in flow, function and coronary flow reserve.; J Am Coll Cardiol; 2001 Jun; 37(7); 1989-1995 |
| Feng J, Schaus BJ, Fallavollita JA, Lee TC, Canty JM; Preload induces troponin I degradation independently of myocardial ischemia.; Circulation; 2001 Apr; 103(16); 2035-2037 |
| Feng J, Schaus BJ, Fallavollita JA, Lee TC & Canty JM Jr; Preload induces troponin degradation independently of myocardial ischemia; Circ. Res.; 2001 Jan; 103; 2035-2037 |
| Kositprapa C, Zhang B, Berger S, Canty JM, Lee TC; Calpain-mediated proteolytic cleavage of troponin I induced by hypoxia or metabolic inhibition in cultured neonatal cardiomyocytes.; Mol Cell Biochem; 2000 Nov; 214(1-2); 47-55 |
| Canty JM; Nitric oxide and short-term hibernation: friend or foe?; Circ Res; 2000 Jul; 87(2); 85-87 |
| Fallavollita JA, Trojan C, Canty JM; Transmural distribution of FDG uptake in stunned myocardium.; Am J Physiol Heart Circ Physiol; 2000 Jul; 279(1); 102-109 |
| Kositprapa C, Zhang B, Berger S, Canty JM Jr. & Lee TC; Calpain-mediated proteolytic cleavage of troponin I induced by hypoxia or metabolic inhibition in cultured neonatal cardiomyocytes; Mol. Cell. Biochem.; 2000 Jan; 214; 47-55 |
| Canty JM, Fallavollita JA; Chronic hibernation and chronic stunning: a continuum.; J Nucl Cardiol; 2000; 7(5); 509-527 |
| Lim H, Fallavollita JA, Hard R, Kerr CW, Canty JM; Profound apoptosis-mediated regional myocyte loss and compensatory hypertrophy in pigs with hibernating myocardium.; Circulation; 1999 Dec; 100(23); 2380-2386 |
| Fallavollita JA, Jacob S, Young RF, Canty JM; Regional alterations in SR Ca(2+)-ATPase, phospholamban, and HSP-70 expression in chronic hibernating myocardium.; Am J Physiol; 1999 Oct; 277(4 Pt); 1418-1428 |
| Thomas SA, Fallavollita JA, Lee TC, Feng J, Canty JM; Absence of troponin I degradation or altered sarcoplasmic reticulum uptake protein expression after reversible ischemia in swine.; Circ Res; 1999 Sep; 85(5); 446-456 |
| Canty JM, Fallavollita JA; Resting myocardial flow in hibernating myocardium: validating animal models of human pathophysiology.; Am J Physiol; 1999 Jul; 277(1 Pt); 417-422 |
| Fallavollita JA, Canty JM; Differential 18F-2-deoxyglucose uptake in viable dysfunctional myocardium with normal resting perfusion: evidence for chronic stunning in pigs.; Circulation; 1999 Jun; 99(21); 2798-2805 |
| Fallavollita JA, Perry BJ, Canty JM; 18F-2-deoxyglucose deposition and regional flow in pigs with chronically dysfunctional myocardium. Evidence for transmural variations in chronic hibernating myocardium.; Circulation; 1997 Apr; 95(7); 1900-1909 |
| Fallavollita JA, Kumar K, Brody AS, Bunnell IL, Canty JM; Detection of coronary artery calcium to differentiate patients with early coronary atherosclerosis from luminally normal arteries.; Am J Cardiol; 1996 Dec; 78(11); 1281-1284 |
| Canty JM, Smith TP; Modulation of coronary autoregulatory responses by endothelium-derived nitric oxide.; Int J Cardiol; 1995 Jul; 50(3); 207-215 |
| Canty JM, Smith TP; Adenosine-recruitable flow reserve is absent during myocardial ischemia in unanesthetized dogs studied in the basal state.; Circ Res; 1995 Jun; 76(6); 1079-1087 |
| Rajagopalan S, Dube S, Canty JM; Regulation of coronary diameter by myogenic mechanisms in arterial microvessels greater than 100 microns in diameter.; Am J Physiol; 1995 Feb; 268(2 Pt); 788-793 |
| Canty JM, Fallavollita JA; Hibernating myocardium represents a primary downregulation of regional myocardial oxygen consumption distal to a critical coronary stenosis.; Basic Res Cardiol; 1995 Jan; 90(1); 5-8 |
| Fallavollita JA, Brody AS, Bunnell IL, Kumar K, Canty JM; Fast computed tomography detection of coronary calcification in the diagnosis of coronary artery disease. Comparison with angiography in patients < 50 years old.; Circulation; 1994 Jan; 89(1); 285-290 |
| Canty JM, Schwartz JS; Nitric oxide mediates flow-dependent epicardial coronary vasodilation to changes in pulse frequency but not mean flow in conscious dogs.; Circulation; 1994 Jan; 89(1); 375-384 |
| Canty JM; Measurement of myocardial perfusion by fast computed tomography.; Am J Card Imaging; 1993 Dec; 7(4); 309-316 |
| Canty JM; Methods of assessing coronary blood flow and flow reserve.; Am J Card Imaging; 1993 Sep; 7(3); 222-232 |
| Satoh S, Klocke FJ, Canty JM; Tone-dependent coronary arterial-venous pressure differences at the cessation of venous outflow during long diastoles.; Circulation; 1993 Sep; 88(3); 1238-1244 |
| Smith TP, Canty JM; Modulation of coronary autoregulatory responses by nitric oxide. Evidence for flow-dependent resistance adjustments in conscious dogs.; Circ Res; 1993 Aug; 73(2); 232-240 |
| Grant BJ, Canty JM, Srinivasan G, Brody AS; Pulmonary arterial elasticity in awake dogs.; J Appl Physiol; 1993 Aug; 75(2); 840-848 |
| Canty JM, Judd RM, Brody AS, Klocke FJ; First-pass entry of nonionic contrast agent into the myocardial extravascular space. Effects on radiographic estimates of transit time and blood volume.; Circulation; 1991 Nov; 84(5); 2071-2078 |
| Farhi ER, Canty JM, Klocke FJ; Dissociation of diastolic pressure-segment length and pressure-wall thickness relations during vasodilation in the conscious dog.; J Am Coll Cardiol; 1991 Sep; 18(3); 850-857 |
| Farhi ER, Klocke FJ, Mates RE, Kumar K, Judd RM, Canty JM, Satoh S, Sekovski B; Tone-dependent waterfall behavior during venous pressure elevation in isolated canine hearts.; Circ Res; 1991 Feb; 68(2); 392-401 |
| Canty JM, Giglia J, Kandath D; Effect of tachycardia on regional function and transmural myocardial perfusion during graded coronary pressure reduction in conscious dogs.; Circulation; 1990 Nov; 82(5); 1815-1825 |
| Canty JM, Brooks A; Phasic volumetric coronary venous outflow patterns in conscious dogs.; Am J Physiol; 1990 May; 258(5 Pt); 1457-1463 |
| Farhi ER, Canty JM, Klocke FJ; Effects of graded reductions in coronary perfusion pressure on the diastolic pressure-segment length relation and the rate of isovolumic relaxation in the resting conscious dog.; Circulation; 1989 Nov; 80(5); 1458-1468 |
| Grant BJ, Canty JM; Effect of cardiac output on pulmonary hemodynamics.; Respir Physiol; 1989 Jun; 76(3); 303-317 |
| Canty JM; Coronary pressure-function and steady-state pressure-flow relations during autoregulation in the unanesthetized dog.; Circ Res; 1988 Oct; 63(4); 821-836 |
| Mates RE, Klocke FJ, Canty JM; Coronary capacitance.; Prog Cardiovasc Dis; 1988 Jul; 31(1); 1-15 |
| Canty JM, Klocke FJ; Reductions in regional myocardial function at rest in conscious dogs with chronically reduced regional coronary artery pressure.; Circ Res; 1987 Nov; 61(5 Pt); 107-116 |
| Klocke FJ, Ellis AK, Canty JM; Interpretation of changes in coronary flow that accompany pharmacologic interventions.; Circulation; 1987 Jun; 75(6 Pt); 34-38 |
| Grant BJB and JM Canty, Jr.; Pulmonary arterial pressure-diameter relations in awake dogs.; Circulation; 1987 May; 76(IV); 469 |
| Canty JM, Klocke FJ, Mates RE; Characterization of capacitance-free pressure-flow relations during single diastoles in dogs using an RC model with pressure-dependent parameters.; Circ Res; 1987 Feb; 60(2); 273-282 |
| CANTY JM; Klocke, F. J., R. E. Mates, J. M. Canty, Jr. and A. K. Ellis. Current controversies concerning coronary pressure-flow relationships. In: Simulation and Control of the Cardiac System. S. Sideman and R. Beyar, editors.; CRC Press; 1987 Jan; |
| CANTY JM; Mates, R. E., F. J. Klocke and J. M. Canty, Jr. Impedance to coronary flow. In: Activation, Metabolism and Perfusion of the Heart. S. Sideman and R. Bayer, editors.; Martinus Nijhoff Publishers, Dordrecht (Netherlands); 1987 Jan; |
| Klocke FJ, Canty JM, Arani DT, Krawczyk JA; Adjustments in regional coronary perfusion accompanying reductions in regional coronary arterial pressure.; Can J Cardiol; 1986 Jul; Suppl; 200-204 |
| Canty JM, Klocke FJ, Mates RE; Pressure and tone dependence of coronary diastolic input impedance and capacitance.; Am J Physiol; 1985 May; 248(5 Pt); 700-711 |
| Klocke FJ, Mates RE, Canty JM, Ellis AK; Coronary pressure-flow relationships. Controversial issues and probable implications.; Circ Res; 1985 Mar; 56(3); 310-323 |
| Canty JM, Klocke FJ; Reduced regional myocardial perfusion in the presence of pharmacologic vasodilator reserve.; Circulation; 1985 Feb; 71(2); 370-377 |
| Aversano T, Klocke FJ, Mates RE, Canty JM; Preload-induced alterations in capacitance-free diastolic pressure-flow relationship.; Am J Physiol; 1984 Mar; 246(3 Pt); 410-417 |
| CANTY JM; Klocke, F. J., J. M. Canty, Jr., and R. E. Mates. Evolving concepts of coronary pressure-flow relationships. In: Functional Aspects of the Normal, Hypertrophied and Failing Heart. F. L. Abel and W.H. Newman, editors.; Martinus Nijhoff Publishing; 1984 Jan; |
| CANTY JM; Mates, R. E., T. Burns, J. M. Canty, R. Greenberg and J. Neeson. Modeling diastolic impedance to coronary blood flow, In: Mechanics of the Coronary Circulation, p. 41-44. American Society of Mechanical Engineers, 1983.; Mechanics of the Coronary Circulation; 1983 Jan; |
| Canty JM, Mates RE; A programmable pressure control system for coronary flow studies.; Am J Physiol; 1982 Nov; 243(5); 796-802 |
| Klocke FJ, Weinstein IR, Klocke JF, Ellis AK, Kraus DR, Mates RE, Canty JM, Anbar RD, Romanowski RR, Wallmeyer KW, Echt MP; Zero-flow pressures and pressure-flow relationships during single long diastoles in the canine coronary bed before and during maximum vasodilation. Limited influence of capacitive effects.; J Clin Invest; 1981 Oct; 68(4); 970-980 |
GRANTS
May 2010 to April 2010
PET/CT for Multidimensional Translational Cardiovascular Research
NIH
John Canty
December 2008 to June 2010
Identify Novel Biomarkers of Arrhythmic Risk Using High-throughput Mass Spectrometry and Serum Proteomics
UB Multi-Investigator proposal Support Program
John Canty
July 2007 to June 2011
Department of Veterans Affairs. Statins and Growth Factors for Chronic Ischemic Heart Failure
John Canty
May 2006 to April 2011
Metabolic Adaptation and Functional Recovery of Hibernating Myocardium
NIH
John Canty
January 2006 to January 2011
NIH National Heart Lung and Blood Institute:Mesenchymal Stem Cell Therapeutics in Hibernating Myocardium
NIH National Heart Lung and Blood Institute
PI:Te-chung Lee
April 2004 to June 2010
Hibernating Myocardium and Sudden Cardiac Death,”
National Heart Lung and Blood Institute
John Canty
March 2003 to February 2010
Chronic Adaptations to Myocardial Ischemia
NIH
John Canty, Techung Lee
$1,466,059