John Crane
Medicine
Associate Professor of Medicine
317 Biomedical Research Building
Buffalo, NY 14215
Phone: (716) 829-2676
Fax: (716) 829-3889
Email: jcrane@acsu.buffalo.edu
URL: http://www.smbs.buffalo.edu/med/ID/images/facultypic/crane.jpg
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OFFICE LOCATIONS
|
Erie County Medical Center 462 Grider St. Buffalo, NY 14215 Phone: 716-898-4759 Fax: 716-829-3889 View Map |
Insurance Accepted Better Health Plan, Inc. (HMO) Community Blue (HMO) Empire Fidelis GHI Independent Health Association (HMO) United Healthcare Univera Health Care (HMO) |
DESCRIPTION OF INTERESTS
| enteropathogenic Escherichia coli (EPEC) and Shiga-toxigenic E. coli (STEC, aka EHEC). EPEC is an important causes of diarrhea among children in developing countries. STEC, such as O157:H7, is more common in developed countrie. A more recent project is the inhibitory effects of zinc on EPEC and STEC. |
SPECIALTIES
Infectious Disease
EDUCATION
| 1990 | Fellowship, Infectious Diseases University of Virginia |
| 1987 | Residency, Medicine University of Rochester, Strong Memorial Hospital |
| 1984 | M.D., MD University of Virginia |
| 1983 | Ph.D., Pharmacology University of Virginia |
EXPERTISE
| E. coli pathogenesis Diarrhea-producing E. coli |
PUBLICATIONS
| Crane JK, Shulgina I; Feedback effects of host-derived adenosine on enteropathogenic Escherichia coli.; FEMS Immunol Med Microbiol; 2009 Dec; 57(3); 214-228 |
| Crane JK, Hoque KM; Zinc for infectious diarrhea in developed countries: should we be sprinkling our own lawns?; J Pediatr Gastroenterol Nutr; 2008 May; 46(5); 484-485 |
| Crane JK, Naeher TM, Shulgina I, Zhu C, Boedeker EC; Effect of zinc in enteropathogenic Escherichia coli infection.; Infect Immun; 2007 Dec; 75(12); 5974-5984 |
| Crane JK, Shulgina I, Naeher TM; Ecto-5'-nucleotidase and intestinal ion secretion by enteropathogenic Escherichia coli.; Purinergic Signal; 2007 Jun; 3(3); 233-246 |
| Crane JK, Choudhari SS, Naeher TM, Duffey ME; Mutual enhancement of virulence by enterotoxigenic and enteropathogenic Escherichia coli.; Infect Immun; 2006 Mar; 74(3); 1505-1515 |
| Crane JK, Naeher TM, Choudhari SS, Giroux EM; Two pathways for ATP release from host cells in enteropathogenic Escherichia coli infection.; Am J Physiol Gastrointest Liver Physiol; 2005 Sep; 289(3); 407-417 |
| CRANE JK; Externalization of host cell protein kinase C during enteropathogenic Escherichia coli infection.; Cell Death and Differentiation; 2003; |
| CRANE JK; Pulmonary mucormycosis in a patient with COPD; diagnosis by fine-needle aspiration cytology.; Journal of Thoracic and Cardiovascular Surgery; 2003; |
| Crane JK, Olson RA, Jones HM, Duffey ME; Release of ATP during host cell killing by enteropathogenic E. coli and its role as a secretory mediator.; Am J Physiol Gastrointest Liver Physiol; 2002 Jul; 283(1); 74-86 |
| Crane JK, McNamara BP, Donnenberg MS; Role of EspF in host cell death induced by enteropathogenic Escherichia coli.; Cell Microbiol; 2001 Apr; 3(4); 197-211 |
| Crane JK; Redistribution of cyclic GMP in response to sodium butyrate in colon cells.; Arch Biochem Biophys; 2000 Apr; 376(1); 163-170 |
| Crane JK; Preformed bacterial toxins.; Clin Lab Med; 1999 Sep; 19(3); 583-599 |
| Aljada IS, Crane JK, Corriere N, Wagle DG, Amsterdam D; Mycobacterium bovis BCG causing vertebral osteomyelitis (Pott's disease) following intravesical BCG therapy.; J Clin Microbiol; 1999 Jun; 37(6); 2106-2108 |
| Crane JK, Majumdar S, Pickhardt DF; Host cell death due to enteropathogenic Escherichia coli has features of apoptosis.; Infect Immun; 1999 May; 67(5); 2575-2584 |
| Kotlarz JP, Crane JK; Toxic shock syndrome after mastoidectomy.; Otolaryngol Head Neck Surg; 1998 May; 118(5); 701-702 |
| Crane JK, Oh JS; Activation of host cell protein kinase C by enteropathogenic Escherichia coli.; Infect Immun; 1997 Aug; 65(8); 3277-3285 |
| Crane JK, Shanks KL; Phosphorylation and activation of the intestinal guanylyl cyclase receptor for Escherichia coli heat-stable toxin by protein kinase C.; Mol Cell Biochem; 1996 Dec; 165(2); 111-120 |
| Crane JK, Shih HT; Syncope and cardiac arrhythmia due to an interaction between itraconazole and terfenadine.; Am J Med; 1993 Oct; 95(4); 445-446 |
| Okhuysen PC, Crane JK, Pappas J; St. Louis encephalitis in patients with human immunodeficiency virus infection.; Clin Infect Dis; 1993 Jul; 17(1); 140-141 |
| Crane JK, Wehner MS, Bolen EJ, Sando JJ, Linden J, Guerrant RL, Sears CL; Regulation of intestinal guanylate cyclase by the heat-stable enterotoxin of Escherichia coli (STa) and protein kinase C.; Infect Immun; 1992 Dec; 60(12); 5004-5012 |
| Levine SA, Donowitz M, Watson AJ, Sharp GW, Crane JK, Weikel CS; Characterization of the synergistic interaction of Escherichia coli heat-stable toxin and carbachol.; Am J Physiol; 1991 Oct; 261(4 Pt); 592-601 |
| Tunkel AR, Crane JK, Hayden FG; Pulmonary nocardiosis in AIDS.; Chest; 1991 Jul; 100(1); 295-296 |
| Crane JK, Burrell LL, Weikel CS, Guerrant RL; Carbachol mimics phorbol esters in its ability to enhance cyclic GMP production by STa, the heat-stable toxin of Escherichia coli.; FEBS Lett; 1990 Nov; 274(1-2); 199-202 |
| Weikel CS, Spann CL, Chambers CP, Crane JK, Linden J, Hewlett EL; Phorbol esters enhance the cyclic GMP response of T84 cells to the heat-stable enterotoxin of Escherichia coli (STa).; Infect Immun; 1990 May; 58(5); 1402-1407 |
| Crane JK, Hewlett EL, Weikel CS; Failure of pertussis toxin to inhibit activation of guanylate cyclase by the heat-stable enterotoxin of Escherichia coli (STa) in the T84 cell line.; Infect Immun; 1989 Apr; 57(4); 1186-1191 |
| Campanile CP, Crane JK, Peach MJ, Garrison JC; The hepatic angiotensin II receptor. I. Characterization of the membrane-binding site and correlation with physiological response in hepatocytes.; J Biol Chem; 1982 May; 257(9); 4951-4958 |
| Crane JK, Campanile CP, Garrison JC; The hepatic angiotensin II receptor. II. Effect of guanine nucleotides and interaction with cyclic AMP production.; J Biol Chem; 1982 May; 257(9); 4959-4965 |
GRANTS
May 2010 to May 2013
Effect of Zinc in Attaching-and-Effacing E. coli infections
NIH, NIAID
John K. Crane
$1,003,901
September 2003 to August 2005
Enteropathogenic and toxigenic E. coli Interactions
NIH
John Crane
Michael E. Duffey
$225,000
September 2003 to January 2006
Host cell killing by EPEC: central role in pathogenesis
NIH, NIAID
John K. Crane
$405,000