Joseph Izzo Joseph Izzo
Medicine
Millard Fillmore Hospital

Phone: (716) 887-4522


OFFICE LOCATIONS

Erie County Medical Center
462 Grider St
Buffalo, NY 14215

Phone: 716-898-3152
View Map
Insurance Accepted
Better Health Plan, Inc. (HMO)
Community Blue (HMO)
Empire
Fidelis
GHI
Independent Health Association (HMO)
Univera Health Care (HMO)


DESCRIPTION OF INTERESTS

(1) Role of the sympathoadrenal system in hypertension, postural adaptation, and long-term cardiovascular adaptation
(2) Control of regional and systemic blood flow during acute stress responses
(3) Mechanisms of stress responses and vacoreactivity, both in vivo and in vitro, including metabolic interactions
(4) Cardiovascular drug effects
(5) Outcomes of drug therapies


SPECIALTIES

Internal Medicine


EDUCATION

1972 MD, Johns Hopkins University
1968 AB, Biology/Biochemistry
Princeton University


EXPERTISE

New Research Expertise


PUBLICATIONS

Chow SL, Luzier AB, DiTusa L, Snyder BD, Izzo JL; Acid-suppressive therapy use associated with antihypertensive agents.; J Clin Pharmacol; 2001 Jul; 41(7); 750-756
Joseph Izzo; Aging and systolic hypertension: cluster patterns and problem-solving strategies to answer the genetic riddle (editorial); Hypertension; 2001 Jul; 37; 1067-1068
Joseph Izzo, Manning, T.S., Shykoff, B.E.; Office blood pressures, arterial compliance characteristics, and estimated cardiac load; Hypertension; 2001 Jul; 38; 1467-1470
Allen, K., Shykoff, B.E., Joseph Izzo; Pet ownership, but not ACE inhibitor therapy, blunts home blood pressure responses to mental stress; Hypertension; 2001 Jul; 38; 815-820
Chow, S.L., Luzier, A.B., DiTusa, L., Snyder, B.D., Joseph Izzo; Acid suppressive therapy use associated with antihypertensive agents; Pharmacoepidemiology; 2001 Jun; 41; 1-7
DiTusa L, Luzier AB, Jarosz DE, Snyder BD, Joseph Izzo; Treatment of hypertension in a managed care setting.; Am J Manag Care; 2001 May; 7(5); 520-524
Joseph Izzo; Aging and systolic hypertension: cluster patterns and problem-solving strategies to answer the genetic riddle.; Hypertension; 2001 Apr; 37(4); 1067-1068
Joseph Izzo, Shykoff, B.E.; Arterial stiffness: clinical relevance, measurement, and treatment; Reviews in Cardiovascular Medicine; 2001 Apr; 2; 29-40
Chaudhuri, A. and Izzo, J.L. Jr.; Insulin resistance and hypertension in the absence of subcutaneous fat; Reviews in Cardiovascular Medicine; 2001 Jan; 1; 120-124
Izzo, J.; A Challenge to JNC VI: Should guidelines for treatment be modified? Blood pressure guidelines and tight blood pressure control is essential; Medical Crossfire; 2000 Sep; 2(9); 45-57
Luzier AB, Forrest A, Feuerstein SG, Izzo JL, Schentag JJ; Containment of heart failure hospitalizations and cost by angiotensin-converting enzyme inhibitor dosage optimization.; Am J Cardiol; 2000 Sep; 86(5); 519-523
Izzo, J.; Systolic hypertension, arterial stiffness and vascular damage: Role of the renin-angiotensin system; Blood Pressure Monitoring; 2000 Jun; 5(suppl); S7-S11
Joseph Izzo; Vascular disease and the renin-system in the patient with hypertension: panel discussion and questions to the audience; Blood Pressure Monitoring; 2000 Jun; 5(suppl); S27-S29
Joseph Izzo, Levy D, Black HR; Clinical Advisory Statement. Importance of systolic blood pressure in older Americans.; Hypertension; 2000 May; 35(5); 1021-1024
Izzo, J.; The role of the renin-angiotensin system in vascular health. Use of ACE inhibition to improve vascular function; Heart Disease; 2000 May; 2(5); 380-383
Luzier AB, Feuerstein SG, Uldrich P, Schentag JJ, Izzo JL Jr.; Containment of heart failure hospitalizations and cost by angiotensin-converting enzyme inhibitor dosage optimization: A demonstration project; Am J Cardiol; 2000 Jan; 86; 519-523
CHAUDHURI A., Izzo, J.L.; Insulin-resistance and hypertension in the absence of subcutaneous fat (case review); Reviews in Cardiovascular Medicine; 2000; 1(2); 120-124
Joseph Izzo; Risk stratification: a key to managing hypertension in the managed care setting.; Am J Manag Care; 1999 Aug; 5(12 Su); 746-751
Sung BH, Izzo JL, Dandona P, Wilson MF; Vasodilatory effects of troglitazone improve blood pressure at rest and during mental stress in type 2 diabetes mellitus.; Hypertension; 1999 Jul; 34(1); 83-88
Bong Sung, Joseph Izzo, Dandona P, Wilson MF; Vasodilatory effects of troglitazone improve blood pressure at rest and during mental stress in type 2 diabetes mellitus.; Hypertension; 1999 Jul; 34(1); 83-88
Joseph Izzo, Taylor AA; The sympathetic nervous system and baroreflexes in hypertension and hypotension.; Curr Hypertens Rep; 1999 Jun; 1(3); 254-263
Sung BH, Ching M, Izzo JL, Dandona P, Wilson MF; Estrogen improves abnormal norepinephrine-induced vasoconstriction in postmenopausal women.; J Hypertens; 1999 Apr; 17(4); 523-528
Bong Sung, Ching M, Joseph Izzo, Dandona P, Wilson MF; Estrogen improves abnormal norepinephrine-induced vasoconstriction in postmenopausal women.; J Hypertens; 1999 Apr; 17(4); 523-528
Huang MH, Knight PR, Joseph Izzo; Ca2+-induced Ca2+ release involved in positive inotropic effect mediated by CGRP in ventricular myocytes.; Am J Physiol; 1999 Jan; 276(1 Pt); 259-264
Huang, M., Knight, P., Joseph Izzo; Ionotropic mechanisms of calcitonin gene-related peptide in isolated ventricular myocytes; Am J Physiol; 1999 Jan; 276; R259-R264
Joseph Izzo; Risk stratification: a key to managing hypertension in the managed care setting; Am J Managed Care; 1999 Jan; 5(Suppl); S746-S751
Joseph Izzo; The hypertension primer project: an educational experiment; Hypertension; 1999 Jan; 33; 167-168
Bong Sung, Joseph Izzo, Paresh Dandona, Michael Wilson; Vasodilatory effects of troglitazone improve blood pressure at rest and during mental stress in type 2 diabetes mellitus; Hypertension; 1999 Jan; 34; 83-88
Luzier AB, Forrest A, Adelman M, Hawari FI, Schentag JJ, Joseph Izzo; Impact of angiotensin-converting enzyme inhibitor underdosing on rehospitalization rates in congestive heart failure.; Am J Cardiol; 1998 Aug; 82(4); 465-469
Sung BH, Ching M, Joseph Izzo, Dandona P, Wilson MF; Insulin-mediated venodilation is impaired in patients with high cholesterol.; Hypertension; 1998 Jun; 31(6); 1266-1271
Joseph Izzo; The microcirculation in hypertension; Current Concepts in Hypertension; 1998 Mar; 2(3); 1-2
Ching MI, Sung BH, Forrest A, Wilson MF, Izzo JL; Vasoreactivity in pre- and postmenopausal women: evaluation by pharmacodynamic modeling.; J Clin Pharmacol; 1998 Feb; 38(2); 151-159
Hawari, F., Shyoff, B., Joseph Izzo; Heparin attenuates norepinephrine-induced vasoconstriction by a cyclic-GMP-mediated mechanism; Vascular Medicine; 1998 Jan; 3; 95-100
Bong Sung, Ching, M., Joseph Izzo, Paresh Dandona, Michael Wilson; Insulin-mediated venodilation is impaired in patients with high cholesterol; Hypertension; 1998 Jan; 31; 1266-1271
Sung BH, Wilson MF, Izzo JL, Ramirez L, Dandona P; Moderately obese, insulin-resistant women exhibit abnormal vascular reactivity to stress.; Hypertension; 1997 Oct; 30(4); 848-853
Sung BH, Wilson MF, Izzo JL, Ramirez L, Dandona P; Moderately obese, insulin-resistant women exhibit abnormal vascular reactivity to stress.; Hypertension; 1997 Oct; 30(4); 848-853
Sung BH, Izzo JL, Wilson MF; Effects of cholesterol reduction on BP response to mental stress in patients with high cholesterol.; Am J Hypertens; 1997 Jun; 10(6); 592-599
Carr JR, Fitzpatrick P, Izzo JL, Cumbo TJ, Birmingham MC, Adelman MH, Paladino JA, Hanson SC, Schentag JJ; Changing the infection control paradigm from off-line to real time: the experience at Millard Fillmore Health System.; Infect Control Hosp Epidemiol; 1997 Apr; 18(4); 255-259
Creager, M.A., Joseph Izzo; Coronary and peripheral vasoreactivity: role of endothelial dysfunction; Current Concepts in Hypertension; 1997 Feb; 2(2); 2-3
Joseph Izzo; Vasoreactivity and high risk hypertension; Current Concepts in Hypertension; 1997 Feb; 2(2); 1-2
Harris LM, Faggioli GL, Shah R, Koerner N, Lillis L, Dandona P, Izzo JL, Snyder B, Ricotta JJ; Vascular reactivity in patients with peripheral vascular disease.; Am J Cardiol; 1995 Jul; 76(3); 207-212
Grover A, Padginton C, Wilson MF, Sung BH, Izzo JL, Dandona P; Insulin attenuates norepinephrine-induced venoconstriction. An ultrasonographic study.; Hypertension; 1995 Apr; 25(4 Pt); 779-784
Grover A, Padginton C, Wilson MF, Sung BH, Izzo JL, Dandona P; Insulin attenuates norepinephrine-induced venoconstriction. An ultrasonographic study.; Hypertension; 1995 Apr; 25(4 Pt); 779-784
Joseph Izzo; Cardiorenal interactions in regulation of blood pressure and volume; Choices in Cardiology; 1992 Jan; 6(suppl); 5-9
Izzo JL, Swislocki AL; Workshop III--Insulin resistance: is it truly the link?; Am J Med; 1991 Feb; 90(2A); 26-31
Izzo JL, Larrabee PS, Sander E, Lillis LM; Hemodynamics of seasonal adaptation.; Am J Hypertens; 1990 May; 3(5 Pt); 405-407
Izzo JL, Sander E, Larrabee PS; Effect of postural stimulation on systemic hemodynamics and sympathetic nervous activity in systemic hypertension.; Am J Cardiol; 1990 Feb; 65(5); 339-342
Izzo JL; Sympathoadrenal activity, catecholamines, and the pathogenesis of vasculopathic hypertensive target-organ damage.; Am J Hypertens; 1989 Dec; 2(12 Pt); 305-312
Izzo JL; The sympathoadrenal system: friend and foe?; Am J Hypertens; 1989 Dec; 2(12 Pt); 303-304
Licht MR, Izzo JL; Humoral effect of norepinephrine on renin release in humans.; Am J Hypertens; 1989 Oct; 2(10); 788-791
Joseph Izzo; Pathophysiology of "volume-dependent hypertension"; IM - Internal Medicine for the Subspecialist; 1988 Dec;
Joseph Izzo; Suitable and unsuitable agents for volume-dependent hypertension; IM - Internal Medicine for the Subspecialist; 1988 Dec;
Joseph Izzo; Selective screening for renovascular disease; Diagnosis; 1988 Jan; 10; 55-64
Sloand JA, Izzo JL; Captopril reduces urinary cystine excretion in cystinuria.; Arch Intern Med; 1987 Aug; 147(8); 1409-1412
Izzo JL, Licht MR, Smith RJ, Larrabee PS, Radke KJ, Kallay MC; Chronic effects of direct vasodilation (pinacidil), alpha-adrenergic blockade (prazosin) and angiotensin-converting enzyme inhibition (captopril) in systemic hypertension.; Am J Cardiol; 1987 Aug; 60(4); 303-308
Izzo JL, Smith RJ, Larrabee PS, Kallay MC; Plasma norepinephrine and age as determinants of systemic hemodynamics in men with established essential hypertension.; Hypertension; 1987 Apr; 9(4); 415-419
Izzo JL, Larrabee PS, Scandling JD; Hyperkalemia with enalapril in advanced renal failure.; JAMA; 1986 May; 255(19); 2605-2606
Blair ML, Chen YH, Izzo JL; Influence of renal perfusion pressure on alpha- and beta-adrenergic stimulation of renin release.; Am J Physiol; 1985 Mar; 248(3 Pt); 317-326
Chen YH, Blair ML, Izzo JL; Renal norepinephrine overflow during graded renal nerve stimulation before and after beta-adrenoceptor blockade.; J Auton Nerv Syst; 1984 Nov; 11(3); 285-295
Daugirdas JT, Ing TS, Chen WT, Vestal RE, Izzo JL, Hano JE, Norusis MJ; Hemodynamic response to volume depletion in acutely uremic dogs.; Am J Physiol; 1984 Aug; 247(2 Pt); H229-H236
Joseph Izzo; The sympathoadrenal system in maintenance of elevated arterial pressure; J Cardiovasc Pharm; 1984 Jun; 6; S514-S521
Izzo JL, Sterns RH; Abnormal norepinephrine release in uremia.; Kidney Int Suppl; 1983 Dec; 16; 221-223
Joseph Izzo; Angiotensin converting enzyme inhibition; ; 1983 Dec;
Joseph Izzo, Sterns, RH; Abnormal norepinephrine release in uremia; Kidney International; 1983 Jan; 24(Suppl); S221-S223
Joseph Izzo, Ghosal, A., Kwong, T., Freeman, R.B., Jaenike, J.R.; Age and prior caffeine use alter the cardiovascular and adrenomedullary responses to oral caffeine; Am. J. Cardiology; 1983 Jan; 52; 769-773
Joseph Izzo; Cardiovascular hormonal effects of circulating norepinephrine; Hypertension; 1983 Jan; 5; 787-789
Izzo JL, Horwitz D, Lawton WJ, Keiser HR; Fludrocortisone suppression of sympathetic nervous activity.; Clin Pharmacol Ther; 1983 Jan; 33(1); 102-106
Joseph Izzo, Horwitz, D., Lawton, W.J., Keiser, H.R.; Fluorocortisone suppression of synpathetic nervous activity; Clin. Pharmacol. Ther.; 1983 Jan; 33; 102-106
Colgan, F.J., Sawa, T., Ten Eyck, L.G., Joseph Izzo; Protective effects of beta blockade on pulmonary function when intracranial pressure is elevated; Crit. Care Medicine; 1983 Jan; 11; 368-372
Joseph Izzo, Greulich, D; Radioenzymatic assay for plasma dihydroxyphenylglycol, dihydroxymandelic acid and dihydroxyphenyl acetic acid in plasma; Life Sci; 1983 Jan; 33; 483-488
Joseph Izzo; Renovascular hypertension: diagnostic problems and therapeutic implications; JAMA; 1983 Jan; 249; 398-399
Izzo JL; Renovascular hypertension: diagnostic problems and therapeutic implications.; JAMA; 1983 Jan; 249(3); 398-399
Joseph Izzo, Izzo, MS, Sterns, RH, Freeman, RB; Sympathetic nervous hyperactivity in maintenance hemodialysis patients; Trans Am Soc Artif Int Organs; 1982 Apr; 28; 528-533
Joseph Izzo; Hypertension in the elderly: a pathophysiological approach to therapy; J Am Geriatrics Soc; 1982 Jan; 30; 352-359
Daugirdas, JT, Ing, TS, Chen, WT, Vestal, RE, Joseph Izzo, Hano, JE, Liu, P; Ultrafiltration hemodynamics in conscious, uremic dogs: effect of using a bicarbonate-buffered, plasma-resembling dialysate; Trans Am Soc Artif Int Organs; 1982 Jan; 28; 528-533
Gutierrez OH, Izzo JL, Burgener FA; Transluminal recanalization of an occluded renal artery: reversal of anuria in a patient with a solitary kidney.; AJR Am J Roentgenol; 1981 Dec; 137(6); 1254-1256
Goldstein DS, Feuerstein G, Izzo JL, Kopin IJ, Keiser HR; Validity and reliability of liquid chromatography with electrochemical detection for measuring plasma levels of norepinephrine and epinephrine in man.; Life Sci; 1981 Feb; 28(5); 467-475
Izzo JL, Horwitz D, Keiser HR; Physiologic mechanisms opposing the hemodynamic effects of prazosin.; Clin Pharmacol Ther; 1981 Jan; 29(1); 7-11
Goldstein DS, Harris AH, Izzo JL, Turkkan JS, Keiser HR; Plasma catecholamines and renin during operant blood pressure conditioning in baboons.; Physiol Behav; 1981 Jan; 26(1); 33-37
Nesbitt GH, Izzo J, Peterson L, Wilkins RJ; Canine hypothyroidism: a retrospective study of 108 cases.; J Am Vet Med Assoc; 1980 Dec; 177(11); 1117-1122
Izzo JL, Roncone AM, Helton DL, Izzo MJ; Subcellular distribution of intraportally injected 125I-labeled insulin in rat liver.; Arch Biochem Biophys; 1979 Nov; 198(1); 97-109
Izzo JL, Horwitz D, Keiser HR; Reduction in human urinary MHPG excretion by guanethidine: urinary MHPG as index of sympathetic nervous activity.; Life Sci; 1979 Apr; 24(15); 1403-1406
Vinci JM, Zusman RM, Izzo JL, Bowden RE, Horwitz D, Pisano JJ, Keiser HR; Human urinary and plasma kinins: relationship to sodium-retaining steroids and plasma renin activity.; Circ Res; 1979 Feb; 44(2); 228-237
Izzo JL; Urinary kallikrein levels and hypertension.; N Engl J Med; 1978 Dec; 299(23); 1316-1317
Vinci JM, Gill JR, Bowden RE, Pisano JJ, Izzo JL, Radfar N, Taylor AA, Zusman RM, Bartter FC, Keiser HR; The kallikrein-kinin system in Bartter's syndrome and its response to prostaglandin synthetase inhibition.; J Clin Invest; 1978 Jun; 61(6); 1671-1682
Izzo J; Cardiovascular hormonal effects of circulating norepinephrine.; Hypertension; 5(5); 787-789
Shykoff BE, Hawari FI, Izzo JL; Diameter, pressure and compliance relationships in dorsal hand veins.; Vasc Med; 6(2); 97-102
Hawari FI, Shykoff BE, Joseph Izzo; Heparin attenuates norepinephrine-induced venoconstriction.; Vasc Med; 3(2); 95-100
Joseph Izzo, Black, H.R., Taubert, K.; Hypertension Primer;
Izzo JL, Santarosa RP, Larrabee PS, Smith RJ, Kallay MC; Increased plasma norepinephrine and sympathetic nervous activity in essential hypertensive and uremic humans: effects of clonidine.; J Cardiovasc Pharmacol; 10 Su; 225-229
Allen K, Golden LH, Joseph Izzo, Ching MI, Forrest A, Niles CR, Niswander PR, Jared Barlow; Normalization of hypertensive responses during ambulatory surgical stress by perioperative music.; Psychosom Med; 63(3); 487-492
O'Donovan RM, Gutierrez OH, Izzo JL; Preservation of renal function by percutaneous renal angioplasty in high-risk elderly patients: short-term outcome.; Nephron; 60(2); 187-192
Vinci JM, Zusman RM, Izzo JL, Bowden RE, Horwitz D, Pisano JJ, Keiser HR; Relationship of human urinary and plasma kinins to sodium-retaining steroids and plasma renin activity.; Adv Exp Med Biol; 120B; 503-514
Izzo JL, Izzo MS, Sterns RH, Freeman RB; Sympathetic nervous system hyperactivity in maintenance hemodialysis patients.; Trans Am Soc Artif Intern Organs; 28; 604-607
Joseph Izzo; Systolic hypertension, arterial stiffness, and vascular damage: role of the renin-angiotensin system.; Blood Press Monit; 5 Sup; 7-11
Perreault MM, Kazierad DJ, Wilton JH, Izzo JL; The effect of isradipine on theophylline pharmacokinetics in healthy volunteers.; Pharmacotherapy; 13(2); 149-153
Zambraski EJ, Ciccone CD, Izzo JL; The role of the sympathetic nervous system in 2-kidney DOCA-hypertensive Yucatan miniature swine.; Clin Exp Hypertens A; 8(3); 411-424
Izzo JL; The sympathoadrenal system in the maintenance of elevated arterial pressure.; J Cardiovasc Pharmacol; 6 Sup; 514-521
Hollenberg NK, Joseph Izzo, Sica DA, White WB, Mansoor GA; Vascular disease and the renin-angiotensin system in the patient with hypertension: panel discussion and questions from the audience.; Blood Press Monit; 5 Sup; 27-29


GRANTS

June 2001 to December 2002
Hemodynamic Profiling of Carvedilol
Glaxo Smith-Kline
Joseph Izzo
$195,000
October 1992 to September 2002
Pilot Clinical Pharmacology Training Program
Food and Drug Administration
Joseph Izzo
January 1989 to December 1994
Coronary Arrhythmia Suppression Trial
NHLBI, NIH
Joseph Izzo
$125,000


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