Umesh Sharma

Umesh Sharma
M.D., Ph.D.

Umesh Sharma M.D., Ph.D.

UBMD Internal Medicine

Specialties

Cardiac pharmacology; Cardiology; Cardiovascular Disease; Drug Development; Gene Expression; Inflammation; Internal Medicine; Preclinical MRI; Radiation Oncology; Translational imaging

Hospital-based provider only
 

Professional Summary:

I am a cardiologist with specialized training in advanced cardiac MRI and a focused interest in cardio-oncology. My clinical and research work centers on cancer therapy–related cardiotoxicity, including immune checkpoint inhibitor–associated myocarditis and cardiovascular complications of CAR T cell therapy. I provide inpatient cardiovascular care at Buffalo General Medical Center and lead MRI-based imaging services at the Gates Vascular Institute.

My translational research program integrates magnetic resonance imaging, immunology, and molecular biology to investigate inflammatory cardiomyopathies. At UB’s Clinical and Translational Research Center, my laboratory develops tissue-targeted MRI techniques and applies them to preclinical and human models to study immune-driven myocardial injury. We are currently investigating T and B cell–mediated mechanisms using engineered cell-based assays, single-cell transcriptomics, and cardiac imaging to identify therapeutic targets in immune checkpoint inhibitor–induced myocarditis.

I actively serve on NIH study sections and editorial boards for cardiovascular journals. Equally important, I mentor medical students, residents, and fellows in both clinical and research settings and precept cardiology fellows at the Heart and Lung Center at BGMC. This mentorship is deeply interwoven with my academic mission: while advancing my own work in cardio-oncology and cardiac imaging, I support the career development of trainees whose research is routinely published in peer-reviewed journals and presented at national and international conferences.

Specialties:

Cardiac pharmacology, Cardiology, Cardiovascular Disease, Drug Development, Gene Expression, Inflammation, Internal Medicine, Preclinical MRI, Radiation Oncology, Translational imaging

Patients Treated:

Adults, Seniors/Elderly

Additional Languages:

Fluent Nepali, Intermediate Hindi

Physician Gender:

Male


Hospital Locations (for inpatients only):

  • Buffalo General Medical Center

Education and Training:

  • Fellowship, Advanced Cardiac Imaging, Massachusetts General Hospital (2013)
  • Fellowship, Cardiovascular Medicine, University of Louisville (2012)
  • Residency, Internal Medicine, Chicago Medical School (2009)
  • PhD, Molecular mechanisms of heart failure, University of Maasricht (2005)
  • MS, Medical Immunology, University of London (2002)
  • , Tribhuvan University (2000)

Awards and Honors:

  • Annual Meeting of the Central Society for Clinical and Translational Research-Travel Award (2018)
  • Emerging Investigator: Circulation Heart Failure (2018)
  • Outstanding Resident (2009)
  • Professionalism Award (2009)

Research Profile:

This UBMD physician is also a member of the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, teaching the next generation of doctors and researching to advance care in WNY and beyond. Learn more about this physician's research and teaching activities, as well as view credentials, publications, professional involvement and more below.


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