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UBMD Physicians' Group
John                           Crane

John K. Crane MD, PhD

UBMD Medicine

Specialties

Infectious Disease; Infectious Diseases; Microbial Pathogenesis; Vitamins and Trace Nutrient

 

Overview

Professional Summary:

I care for patients who are hospitalized at Erie County Medical Center where I also serve as the hospital epidemiologist addressing infection control.

I teach medical students, residents, and fellows in both hospital and classroom settings. In UB’s schools of medicine and dentistry, I teach a variety of topics including microbiology, pharmacology and toxicology, oral biology, and gastrointestinal systems, host defenses, and global health.

I also conduct laboratory research on diarrhea-producing strains of E. coli bacteria. My lab focuses on enteropathogenic Escherichia coli (EPEC), Shiga-toxigenic E. coli (STEC, aka EHEC) and enterotoxigenic E. coli (ETEC). We are working on the role of intestinal host defenses such as nitric oxide and on the immune modulatory effects of adenosine. We have discovered that zinc can directly inhibit the virulence of pathogenic bacteria, and we are working on turning these laboratory findings into treatments. In our work on zinc we collaborate with Michael Duffey, PhD, in the Department of Physiology and Biophysics.

Recently we have discovered that zinc can inhibit the development of resistance to antibiotics in Escherichia coli and other bacteria. Zinc does this by its ability to inhibit the SOS response, a bacterial stress response triggered by damage to the bacterial DNA. We are collaborating with Dr. Mark Sutton of Biochemistry to better determine the mechanism of zinc in this regard.

I am interested in international medicine and global health and participate in an annual medical mission trip to Honduras, a trip in which student volunteers are encouraged to participate. Closer to home, I am a volunteer physician at Good Neighbors Health Center, a free clinic for the underserved on Jefferson Avenue in Buffalo. Resident physicians are encouraged to volunteer, and students may also be able to arrange clinical experiences.

I am Co-Medical Director, with Dr. Ryosuke Osawa, of the Erie County TB Clinic.

Learning experiences in my laboratory, in infection prevention and hospital epidemiology, or in international health, may be available for motivated students, residents, and fellows.

Specialties:

Infectious Disease, Infectious Diseases, Microbial Pathogenesis, Vitamins and Trace Nutrient

Additional Languages:

Intermediate Spanish

Physician Gender:

Male


Location and Insurance

Hospital Locations (for inpatients only):
  • Erie County Medical Center
Insurance Accepted:
  • Blue Cross & Blue Shield of WNY Inc
  • Empire
  • Fidelis
  • GHI
  • Independent Health Association (HMO)
  • Magnacare
  • Medicaid
  • Medicare
  • MVP Healthcare
  • NYS Medicaid
  • United Healthcare
  • Univera Health Care (HMO)

Credentials

Education and Training:
  • Fellowship, Infectious Diseases, University of Virginia (1990)
  • Residency, Medicine, University of Rochester, Strong Memorial Hospital (1987)
  • MD, MD, University of Virginia (1984)
  • PhD, Pharmacology, University of Virginia (1983)
Awards and Honors:
  • Cover Photo, Infection & Immunity (2016)
  • Runner-Up, Outstanding Physician Award, ECMC (2016)
  • Outstanding Physician Award Nominee (2016)
  • Certified, Ebola Treatment Center, New York State (2015)
  • NYS Hospital Acquired Infections Technical Advisory Group (2012)
  • Mentor for Recipient of IDSA Medical Scholar Award, 2012 (2012)
  • Amer Soc. for Microbiol Minority Mentor Award (2011)
  • Mentor for Recipient of IDSA Student Scholar Award, 2011 (2011)
  • Fellow of the Infectious Diseases Society of America (2009)
  • American Society for Microbiology Service Award (2008)

Research

Research Profile:

This UBMD clinician teaches at the University at Buffalo's School of Medicine and Biomedical Sciences. Learn more about this clinician’s research and teaching activities. View credentials, publications, professional involvement and more.