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UBMD Physicians' Group
Matthew                        Barth

Matthew J. Barth MD

UBMD Pediatrics


Pediatric Hematology-Oncology; Pediatrics



Professional Summary:

I am a pediatric hematologist/oncologist. I see patients in UBMD pediatric outpatient clinics, and I care for young patients who are admitted to Roswell Park Cancer Institute (RPCI).

In addition to my clinical practice, I have a keen interest in hematological malignancies and the use of targeted therapies in their treatment. As a fellow in the lymphoma translational research laboratory at RPCI, I began investigating novel therapeutic anti-CD20 antibodies in cell-line and xenograft models of rituximab resistant B-cell non-Hodgkin lymphoma (B-NHL). Based on my initial findings with the antibody ofatumumab, the University at Buffalo granted me the Dr. Henry C. and Bertha H. Buswell Fellowship, an award for promising physician-scientists who are in the beginning stages of their careers. The award allowed me to continue my work with this novel monoclonal antibody and begin exploring why B-cell lymphoma cells become resistant to multiple therapeutic modalities, including anti-CD20 immunotherapy and traditional cytotoxic chemotherapy. For children with relapsed/refractory disease, this resistance portends a survival rate that is less than 20 percent.

Using cell-line models of resistant disease and a variety of techniques such as gene expression profiling, phosphoproteomics, phospho-flow cytometry and western blotting, I have sought to characterize aberrant signal transduction pathway activation in the setting of resistant B-NHL and the ability to target relevant pathways as a means to overcome or bypass therapeutic resistance. These efforts have led to collaborative research with several investigators throughout the country who have similar interests, e.g., the clinical investigation of the anti-CD20 monoclonal antibody rituximab in childhood B-NHL.

In addition to my basic science and translational research, I am involved in developing trials that investigate other novel therapies in the setting of relapsed/refractory disease. I am co-PI of an investigator-initiated trial studying the anti-CD20 monoclonal antibody obinutuzumab, in combination with chemotherapy, for relapsed/refractory childhood B-NHL. I am also an industry-sponsored investigator researching the role of rituximab in the treatment of de novo childhood mature B-NHL. Additionally, I serve on the study committees of ongoing clinical trials through the Children’s Oncology Group.

I often supervise residents on their research projects and periodically welcome medical students, college students and high school students to work with me in the lab—mostly as part of the RPCI summer research program.

I teach medical students, residents and fellows rotating through pediatric hematology and oncology, in outpatient clinics and at the bedside on inpatient units. Using brief impromptu lectures/discussions, I also teach these trainees about disease processes they encounter as they rotate through hematology/oncology. I also lecture the pediatric residents during the hematology/oncology portion of their didactic series. Additionally, I teach our hematology/oncology fellows, in small-group didactic lectures and in both inpatient and outpatient clinical encounters.


Pediatric Hematology-Oncology, Pediatrics

Patients Treated:

Children, Adolescents

Physician Gender:


Location and Insurance

UBMD at Roswell Park Cancer Institute
Katherine, Anne and Donna Gioia Pediatric Hematology Oncology Center
Roswell Park Cancer Institute
Elm and Carlton Streets
Ground Floor
Buffalo, NY 14263
Phone: (716) 845-4447
Fax: (716) 845-3588
Accepting new patients

UBMD Pediatrics Outpatient Center
Southwestern Office Park
4535 Southwestern Blvd
Suite 712
Hamburg, NY 14075
Office Hours: Monday (2nd & 4th): 8:00 am-12:00 pm
Phone: (716) 878-7349
Fax: (716) 888-3801
Accepting new patients

Insurance Accepted:
  • Aetna U.S. Healthcare
  • Blue Cross & Blue Shield of WNY Inc
  • CIGNA HealthCare
  • Community Blue (HMO)
  • Community Blue Advantage
  • Coventry
  • Empire
  • Fidelis
  • Independent Health Association (HMO)
  • Independent Health Medisource
  • Lifetime Benefit Solutions / RMSCO
  • Magnacare
  • Medicaid
  • Medicare
  • MVP Healthcare
  • Nofault
  • North American Administrators
  • Nova
  • Preferred Care
  • Railroad Medicare
  • Tricare
  • TriCare/Champus
  • United Healthcare
  • Univera Health Care (HMO)
  • Veterans Administration
  • WellCare
  • Workers Comp
  • YourCare


Board Certifications:
  • Board Certification, American Board of Pediatrics
  • Board Certification, American Board of Pediatrics, Sub-board in Pediatric Hematology/Oncology
Education and Training:
  • Fellowship, Pediatric Hematology/Oncology, University at Buffalo (2011)
  • Residency, Pediatrics, University at Buffalo (2008)
  • Internship, Pediatrics, University at Buffalo (2006)
  • MD, Medicine, SUNY Upstate Medical University (2005)
  • BA, Chemistry, Stonehill College, cum laude (1999)
  • BS, Biology, Stonehill College, cum laude (1999)
Awards and Honors:
  • Healio: Hematology/Oncology Today's Next Gen Innovators Nomination (2017)
  • International Society of Paediatric Oncology: Young Investigator Award (2016)
  • 5th International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma: Outstanding Translational Biology Research (2015)
  • National Institutes of Health: Loan Repayment Program Award (2012)
  • 11th International Conference on Malignant Lymphoma: Travel Award (2011)
  • Roswell Park Cancer Institute: Best Basic Science Fellow Research Report (2011)
  • University at Buffalo Jacobs School of Medicine and Biomedical Sciences: Thomas F. Frawley, MD Residency Research Fellowship (2011)
  • University at Buffalo Jacobs School of Medicine and Biomedical Sciences: Henry C. and Bertha H. Buswell Fellowship (2011)


Research Profile:

This UBMD clinician teaches at the University at Buffalo's School of Medicine and Biomedical Sciences. Learn more about this clinician’s research and teaching activities. View credentials, publications, professional involvement and more.